EMD-55776

Single-particle
2.57 Å
EMD-55776
3D View Gallery
Deposition: 20/11/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55776

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9tc7 summary report (pdf.gz) Map-9tc7 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Inactive-state structure of GPR55 in complex with BI-6229

EMD-55776

Single-particle
2.57 Å
EMD-55776
3D View Gallery
Deposition: 20/11/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Synthetic construct, Homo sapiens
Sample: GPR55-bRIL-Fab-Nb-BI-6229
Fitted models: 9tc7

Deposition Authors: Claff T , Ebenhoch R , Kley JT , Weichert D
Molecular insights into GPR55 modulation reveal an atypical activation mechanism and glycosylation-dependent efficacy regulation.
Claff T , Demalgiriya-Gamage C, Mahardhika AB , Stamos NA , Bangnowski F, Sun X, Durr KL , Robinson CV , Haney R, Frego L, Nar H , Muller CE , Ebenhoch R , Kley JT , Weichert D
(2026) Nat Commun , 17
PUBMED: 42926240
DOI: doi:10.1038/s41467-026-78538-1
ISSN: 2041-1723
Grant Support: