EMD-55558

Single-particle
7.8 Å
EMD-55558
3D View Gallery
Deposition: 03/11/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55558

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

The Cullin 2 RING VHL E3 ligase dimerized by the homoPROTAC CM11, C1 symmetry

EMD-55558

Single-particle
7.8 Å
EMD-55558
3D View Gallery
Deposition: 03/11/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11

Deposition Authors: Crowe C , Ciulli A
Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes
Crowe C , Salerno A, Sathe G, Marsh G, Maple H, Ciulli A
(2025) bioRxiv
DOI: doi:10.1101/2025.11.18.689129
ISSN: 2692-8205