EMD-55257

Single-particle
2.51 Å
EMD-55257
3D View Gallery
Deposition: 03/10/2025
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55257

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9svg summary report (pdf.gz) Map-9svg FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of CRBN bound to 2-[5-chloro-1-(4-piperidyl)indol-4-yl]-2,5-diazaspiro[3.4]octan-6-one in the open conformation

EMD-55257

Single-particle
2.51 Å
EMD-55257
3D View Gallery
Deposition: 03/10/2025
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of CRL4 E3 adapter-receptor pair DDB1 and CRBN bound to spirocyclic ligand
Fitted models: 9svg

Deposition Authors: Cowan AD, Rutter ZJ, McAulay K, Ciulli A

Structural and Biophysical Methods for the Assessment of Cereblon Binders for PROTACs
Rutter ZJ, Cowan AD, McAulay K, Ciulli A
To Be Published
Grant Support: