EMD-55233

Single-particle
4.3 Å
EMD-55233
3D View Gallery
Deposition: 30/09/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55233
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9sv3 summary report (pdf.gz) Map and 9sv3 FULL report (pdf.gz)
EMICSS annotations (xml)

Local refinement of EloB/EloC/VHL/CV2a/14-3-3zeta/ERa from pose 1

EMD-55233

Single-particle
4.3 Å
EMD-55233
3D View Gallery
Deposition: 30/09/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Quaternary complex of the VCB (VHL-EloC-EloB) E3 ligase von Hippel-Lindau substrate receptor in complex with small molecule CV2a, 14-3-3zeta and the estrogen receptor alpha
Fitted models: 9sv3

Deposition Authors: Crowe C, Nakasone MA, Harzing T, Verhoef CJA, Cossar PJ, Ciulli A
Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design
Verhoef CJA, Crowe C, Nakasone MA, DeLaCuadra-Baste A, Harzing T, Span NAS, Sathe G, Iso K, Ottmann C, Brunsveld L, Ciulli A, Cossar PJ
(2025) bioRxiv
DOI: doi:10.1101/2025.11.17.688825
ISSN: 2692-8205