EMD-55233

Single-particle
4.3 Å
EMD-55233
3D View Gallery
Deposition: 30/09/2025
Map released: 03/12/2025
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55233

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9sv3 summary report (pdf.gz) Map-9sv3 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Local refinement of EloB/EloC/VHL/CV2a/14-3-3zeta/ERa from pose 1

EMD-55233

Single-particle
4.3 Å
EMD-55233
3D View Gallery
Deposition: 30/09/2025
Map released: 03/12/2025
Last modified: 02/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Quaternary complex of the VCB (VHL-EloC-EloB) E3 ligase von Hippel-Lindau substrate receptor in complex with small molecule CV2a, 14-3-3zeta and the estrogen receptor alpha
Fitted models: 9sv3

Deposition Authors: Crowe C, Nakasone MA, Harzing T, Verhoef CJA, Cossar PJ, Ciulli A
Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC.
Verhoef CJA, Crowe C, Nakasone MA, DeLaCuadra-Baste A, Harzing T, Span NAS, Sathe G, Demmers LC, Iso K, Ottmann C, Brunsveld L, Ciulli A, Cossar PJ
(2026) Nat Commun , 17
PUBMED: 42457718
DOI: doi:10.1038/s41467-026-75333-w
ISSN: 2041-1723