EMD-54630
Ternary cryo-EM structure of human ALG9 with Dol25-PP-GlcNAc2Man6, Dol25-P-Man and Fab
EMD-54630
Single-particle2.89 Å
Deposition: 01/08/2025Map released: 18/03/2026
Last modified: 18/03/2026
Sample Organism:
synthetic construct,
Homo sapiens,
Lama glama
Sample: Ternary complex of human ALG9 with Hs9-8 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man6 substrates
Fitted models: 9s6s
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S,
de Capitani M,
Irobalieva RN,
Rossi L,
Agrawal P,
Kowal J,
Meirelles MA,
Aebi M,
Reymond JL,
Kossiakoff AA,
Riniker S,
Locher KP
Sample: Ternary complex of human ALG9 with Hs9-8 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man6 substrates
Fitted models: 9s6s
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S,
de Capitani M,
Irobalieva RN,
Rossi L,
Agrawal P,
Kowal J,
Meirelles MA,
Aebi M,
Reymond JL,
Kossiakoff AA,
Riniker S,
Locher KP
Structural basis for oligomannose N-glycan synthesis in the endoplasmic reticulum
Alexander JAN ,
Chen SY,
Mukherjee S,
de Capitani M,
Irobalieva RN,
Rossi L,
Agrawal P,
Kowal J,
Meirelles MA,
Aebi M,
Reymond JL,
Kossiakoff AA,
Riniker S,
Locher KP
(2026) Nat Chem Biol
,
Chen SY,
Mukherjee S,
de Capitani M,
Irobalieva RN,
Rossi L,
Agrawal P,
Kowal J,
Meirelles MA,
Aebi M,
Reymond JL,
Kossiakoff AA,
Riniker S,
Locher KP
(2026) Nat Chem Biol
Grant Support:
- Swiss National Science Foundation: 310030_196862 (Switzerland)
- Swiss National Science Foundation: 315230_220007 (Switzerland)