Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-54511

Single-particle
3.2 Å
EMD-54511
3D View Gallery
Deposition: 22/07/2025
Map released: 08/10/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54511
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9s2u summary report (pdf.gz) Map and 9s2u FULL report (pdf.gz)
EMICSS annotations (xml)

1:1 complex of M.tuberculosis MmpL5 and M.smegmatis AcpM

EMD-54511

Single-particle
3.2 Å
EMD-54511
3D View Gallery
Deposition: 22/07/2025
Map released: 08/10/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mycobacterium tuberculosis, Aequorea victoria, Mycolicibacterium smegmatis MC2 155
Sample: 1:1 complex of M.tuberculosis MmpL5 and M.smegmatis AcpM
Fitted models: 9s2u

Deposition Authors: Fountain AJ , Luisi BF , Ramakrishan L
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
Fountain AJ , Bohning J, McLaughlin SH , Morgan TE, Edelstein PH , Troll M, Lamers MH, Bharat TAM , Luisi BF , Ramakrishnan L
(2025) PNAS , 122 , e2516660122 - e2516660122
PUBMED: 40986343
DOI: doi:10.1073/pnas.2516660122
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: