EMD-54418
Cryo-EM structure of human NHE6 in C1 symmetry
EMD-54418
Single-particle3.5 Å
Deposition: 16/07/2025Map released: 29/07/2026
Last modified: 29/07/2026
Sample Organism:
Homo sapiens
Sample: Homodimeric human NHE6 in C1 symmetry
Fitted models: 9s0r
Deposition Authors: Feilen LP
,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
Sample: Homodimeric human NHE6 in C1 symmetry
Fitted models: 9s0r
Deposition Authors: Feilen LP
,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
Integrative structural analysis of the human endosomal Na/H exchanger NHE6 reveals lipid-modulated gating of the ion-binding site
Feilen LP ,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
To Be Published
,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
To Be Published
Grant Support:
- Novo Nordisk Foundation: NNF20OC0060692 (Denmark)
- The Carlsberg Foundation: CF20-0533 (Denmark)
- Independent Research Fund Denmark - Medical Sciences: 1131-00023B (Denmark)
- European Research Council (ERC): 101151923 (European Union)
- Danish Council for Independent Research: 3103-00217B (Denmark)