EMD-54362

Single-particle
3.99 Å
EMD-54362
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54362
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9rx9 summary report (pdf.gz) Map and 9rx9 FULL report (pdf.gz)
EMICSS annotations (xml)

VPS34-CII bound to RAB5A-GTP 1-212 (C19S, C63S, Q79L) on the VPS34 subunit, primary map processed with CryoTEN

EMD-54362

Single-particle
3.99 Å
EMD-54362
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG) incubated with 22-fold molar excess of RAB5A-GTP (C19S, C63S, Q79L)
Fitted models: 9rx9

Deposition Authors: Spokaite S, Ohashi Y, Dessus AN, Bourguet M, Williams RL
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution.
Spokaite S, Ohashi Y, Bourguet M, Dessus AN, Williams RL
(2026) eLife , 15
PUBMED: 42207670
DOI: doi:10.7554/eLife.110040
ISSN: 2050-084X