EMD-54313

Single-particle
3.15 Å
EMD-54313
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Deposition: 09/07/2025
Map released: 03/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54313
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EMICSS annotations (xml)

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L, focused refinement on the kinase arm)

EMD-54313

Single-particle
3.15 Å
EMD-54313
3D View Gallery
Deposition: 09/07/2025
Map released: 03/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human VPS34-CII (VPS34/VPS15/BECLIN1/UVRAG) in complex with RAB5A-GTP (C19S, C63S, Q70L)

Deposition Authors: Spokaite S , Ohashi Y , Bourguet M , Dessus AN , Williams RL
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution.
Spokaite S , Ohashi Y , Bourguet M , Dessus AN , Williams RL
(2026) eLife , 15
PUBMED: 42207670
DOI: doi:10.7554/eLife.110040
ISSN: 2050-084X