EMD-54287
Structure of human 1918 influenza A polymerase heterotrimer in complex with 1918 NEP.
EMD-54287
Single-particle2.53 Å
Deposition: 08/07/2025Map released: 24/12/2025
Last modified: 04/02/2026
Sample Organism:
Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Sample: Structure of human 1918 influenza A polymerase heterotrimer in complex with 1918 NEP
Fitted models: 9rve
Deposition Authors: Rep A
,
Wang F ,
Chen K,
Carrique L ,
Grimes JM ,
Fodor E
Sample: Structure of human 1918 influenza A polymerase heterotrimer in complex with 1918 NEP
Fitted models: 9rve
Deposition Authors: Rep A
,
Wang F ,
Chen K,
Carrique L ,
Grimes JM ,
Fodor E
Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex.
Rep A ,
Wang F ,
Chen KY ,
Carrique L ,
Sharps J,
Grimes JM ,
Fodor E
(2026) Sci Adv , 12 , eaeb4073 - eaeb4073
,
Wang F ,
Chen KY ,
Carrique L ,
Sharps J,
Grimes JM ,
Fodor E
(2026) Sci Adv , 12 , eaeb4073 - eaeb4073
Grant Support:
- Wellcome Trust: 200835/Z/16/Z (United Kingdom)
- Wellcome Trust: 222510/Z/21/Z (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/R009945/1 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/X008312/1 (United Kingdom)
- Wellcome Trust: 093305/Z/10/Z (United Kingdom)
- Wellcome Trust: 060208/Z/00/Z (United Kingdom)
- Wellcome Trust: 203141/Z/16/Z (United Kingdom)
- Wellcome Trust: 227570/Z/23/Z (United Kingdom)