EMD-54216

Single-particle
3.38 Å
EMD-54216
3D View Gallery
Deposition: 01/07/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54216
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9rsd summary report (pdf.gz) Map and 9rsd FULL report (pdf.gz)
EMICSS annotations (xml)

Ternary complex of a charged molecular glue degrader ZZ1-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26

EMD-54216

Single-particle
3.38 Å
EMD-54216
3D View Gallery
Deposition: 01/07/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ZZ1-SO2H-induced complex between YPEL5-CTLH E3 ligase and the first bromodomain (BD1) of BRD4
Fitted models: 9rsd

Deposition Authors: Chrustowicz J, Schulman BA

Molecular Glue Prodrug Discovery Enabled by Targeted Degron Display
Zhuang Z, Woong Sub B, Chrustowicz J, Kozicka Z, Hinshaw SM, Li VL, Donovan KA, Sepic S, You I, Slabicki M, Fischer ES, Ebert BL, Schulman BA, Gray NS
To Be Published