EMD-54194

Single-particle
11.77 Å
EMD-54194
3D View Gallery
Deposition: 27/06/2025
Map released: 08/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54194

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

ZZ1-SO2H-induced assembly of the YPEL5-CTLH E3 ligase and BRD4(BD1) neosubstrate

EMD-54194

Single-particle
11.77 Å
EMD-54194
3D View Gallery
Deposition: 27/06/2025
Map released: 08/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ZZ1-SO2H-induced complex of YPEL5-CTLH E3 ligase and the first bromodomain (BD1) of BRD4

Deposition Authors: Chrustowicz J , Schulman BA
Charged molecular glue discovery enabled by targeted degron display.
Zhuang Z, Byun WS, Chrustowicz J , Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Slabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA , Gray NS
(2026) Nat Chem Biol
PUBMED: 41942733
DOI: doi:10.1038/s41589-026-02182-5
ISSN: 1552-4469