EMD-54186

Single-particle
2.3 Å
EMD-54186
3D View Gallery
Deposition: 27/06/2025
Map released: 13/05/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54186

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rrf summary report (pdf.gz) Map-9rrf FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

TRPC5 apo cryoEM map in the presence of pluronic acid (PA), state 2

EMD-54186

Single-particle
2.3 Å
EMD-54186
3D View Gallery
Deposition: 27/06/2025
Map released: 13/05/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: TRPC5 in presence of pluronic acid
Fitted models: 9rrf

Deposition Authors: Porav AS, Bon RS, Muench S
(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation.
Porav SA, Ptakova A, Bauer CC, Hammond KLR, Beech DJ, Vlachova V, Muench SP, Bon RS
(2026) Nat Commun , 17
PUBMED: 42056091
DOI: doi:10.1038/s41467-026-71840-y
ISSN: 2041-1723