EMD-54077
Structure of BAF-nucleosome complex with OCT4-SOX2 at SHL+6 in ADP-bound state, BAF47 bound to ATPase lobe 2
EMD-54077
Single-particle5.9 Å
Deposition: 19/06/2025Map released: 11/02/2026
Last modified: 09/09/2026
Sample Organism:
Homo sapiens,
synthetic construct
Sample: BAF in complex with a OCT4/SOX2-bound nucleosome
Fitted models: 9rn1
Deposition Authors: Domjan D
,
Weiss J,
Cavadini S,
Veccia L,
Kempf G,
Kater L,
Pathare G,
Thoma NH
Sample: BAF in complex with a OCT4/SOX2-bound nucleosome
Fitted models: 9rn1
Deposition Authors: Domjan D
,
Weiss J,
Cavadini S,
Veccia L,
Kempf G,
Kater L,
Pathare G,
Thoma NH
The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4-SOX2.
Weiss J,
Vecchia L,
Domjan D ,
Cavadini S,
Sabantsev A,
Kempf G,
Pathare GR,
Brackmann K,
Michael AK,
Kater L,
Hietter-Pfeiffer E,
Haddawi M,
Kuber UP ,
Muhlhausser S,
Grand RS,
Stadler MB,
Deindl S,
Thoma NH
(2026) Mol Cell , 86 , 625 - 639.e8
,
Cavadini S,
Sabantsev A,
Kempf G,
Pathare GR,
Brackmann K,
Michael AK,
Kater L,
Hietter-Pfeiffer E,
Haddawi M,
Kuber UP ,
Muhlhausser S,
Grand RS,
Stadler MB,
Deindl S,
Thoma NH
(2026) Mol Cell , 86 , 625 - 639.e8
Grant Support:
- Swiss National Science Foundation: (Switzerland)
- European Research Council (ERC): (European Union)
- European Molecular Biology Organization (EMBO): (European Union)
- Other private:
- Other private: