EMD-54071
CryoEM reconstruction of integrase filament at the lumen of native HIV-1 cores (box size 34.2 nm)
EMD-54071
Single-particle4.63 Å
Deposition: 19/06/2025Map released: 10/12/2025
Last modified: 24/06/2026
Sample Organism:
Human immunodeficiency virus 1
Sample: Human immunodeficiency virus 1
Fitted models: 9rmx
Deposition Authors: Cherepanov P
,
Singer MR,
Hope J ,
Zhang P
Sample: Human immunodeficiency virus 1
Fitted models: 9rmx
Deposition Authors: Cherepanov P
,
Singer MR,
Hope J ,
Zhang P
Integrase anchors viral RNA to the HIV-1 capsid interior.
Singer MR,
Li Z,
Rey JS ,
Hope J ,
Chenavier F ,
Cook NJ ,
Punch E,
Smith J,
Zhou Z ,
Maslen S,
Masino L ,
Nans A ,
Skehel M,
Taylor IA ,
Zanetti G ,
Zhang P ,
Perilla JR ,
Engelman AN ,
Cherepanov P
(2026) Nature , 652 , 1068 - 1075
,
Hope J ,
Chenavier F ,
Cook NJ ,
Punch E,
Smith J,
Zhou Z ,
Maslen S,
Masino L ,
Nans A ,
Skehel M,
Taylor IA ,
Zanetti G ,
Zhang P ,
Perilla JR ,
Engelman AN ,
Cherepanov P
(2026) Nature , 652 , 1068 - 1075
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U54AI170791 (United States)
- Wellcome Trust: CC2058 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): CC2058 (United Kingdom)
- Cancer Research UK: CC2058 (United Kingdom)