EMD-53969
FZD7 in complex with negative allosteric modulator C407
EMD-53969
Single-particle2.5 Å
Deposition: 09/06/2025Map released: 24/12/2025
Last modified: 24/12/2025
Sample Organism:
Spodoptera frugiperda,
Homo sapiens
Sample: FZD7 in complex with the negative allosteric modulator C407
Fitted models: 9rhg
Deposition Authors: Scharf MM
,
Graetz L,
Kinsolving J ,
Voss J,
Carrasco-Busturia D ,
Forsberg B,
Kolb P ,
Schulte G
Sample: FZD7 in complex with the negative allosteric modulator C407
Fitted models: 9rhg
Deposition Authors: Scharf MM
,
Graetz L,
Kinsolving J ,
Voss J,
Carrasco-Busturia D ,
Forsberg B,
Kolb P ,
Schulte G
In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.
Scharf MM ,
Kinsolving J ,
Gratz L,
Voss JH ,
Carrasco-Busturia D ,
Forsberg B,
Kolb P ,
Schulte G
(2025) Nat Commun , 16 , 11138 - 11138
,
Kinsolving J ,
Gratz L,
Voss JH ,
Carrasco-Busturia D ,
Forsberg B,
Kolb P ,
Schulte G
(2025) Nat Commun , 16 , 11138 - 11138
Grant Support:
- Swedish Research Council: 2017-04676 (Sweden)
- Swedish Research Council: 2019-01190 (Sweden)
- Swedish Research Council: 2024-02515 (Sweden)
- Cancerfonden: CAN2017/561 (Sweden)
- Cancerfonden: 20 1102 PjF (Sweden)
- Cancerfonden: 23 2825 Pj (Sweden)
- Novo Nordisk Foundation: NNF21OC0070008 (Denmark)
- Novo Nordisk Foundation: NNF22OC0078104 (Denmark)
- German Research Foundation (DFG): 504098926 (Germany)
- German Research Foundation (DFG): 470002134 (Germany)
- German Research Foundation (DFG): 520506488 (Germany)
- Knut and Alice Wallenberg Foundation: KAW 2020.0239 (Sweden)
- European Union (EU): 101199012 (European Union)
- Swedish Research Council: 2022-06725 (Sweden)