EMD-53943

Single-particle
2.4 Å
EMD-53943
3D View Gallery
Deposition: 05/06/2025
Map released: 27/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53943

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rfw summary report (pdf.gz) Map-9rfw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Manikomycin bound to the Escherichia coli 50S ribosomal subunit

EMD-53943

Single-particle
2.4 Å
EMD-53943
3D View Gallery
Deposition: 05/06/2025
Map released: 27/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Escherichia coli BW25113, Streptomyces rimosus
Sample: Manikomycin bound 50S ribosomal subunit
Fitted models: 9rfw

Deposition Authors: Kaur M, Travin D, Berger MJ, Jangra M, Morici M, Safdari HA, Guitor AK, Koteva K, Xu M, Chen X, Vazquez-Laslop N, Mankin AS, Wilson DN, Wright G
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.
Kaur M, Travin DY, Berger MJ, Jangra M, Morici M, Safdari HA, Klepacki D, Wang W, Cook M, Chou S, Guitor AK, Koteva K, Xu M, Ejim L, Fiebig A, Yousefi Y, Coombes BK, Macneil L, Vazquez-Laslop N, Mankin AS, Wilson DN, Wright GD
(2026) Nature , 655 , 737 - 746
PUBMED: 42236948
DOI: doi:10.1038/s41586-026-10589-2
ISSN: 1476-4687
ASTM: NATUAS