EMD-53943

Single-particle
2.4 Å
EMD-53943
3D View Gallery
Deposition: 05/06/2025
Map released: 27/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53943

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rfw summary report (pdf.gz) Map-9rfw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Manikomycin bound to the Escherichia coli 50S ribosomal subunit

EMD-53943

Single-particle
2.4 Å
EMD-53943
3D View Gallery
Deposition: 05/06/2025
Map released: 27/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Escherichia coli BW25113, Streptomyces rimosus
Sample: Manikomycin bound 50S ribosomal subunit
Fitted models: 9rfw

Deposition Authors: Kaur M, Travin D , Berger MJ, Jangra M , Morici M , Safdari HA , Guitor AK , Koteva K , Xu M , Chen X, Vazquez-Laslop N , Mankin AS, Wilson DN, Wright G
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.
Kaur M, Travin DY, Berger MJ, Jangra M , Morici M , Safdari HA , Klepacki D, Wang W, Cook M, Chou S, Guitor AK , Koteva K , Xu M , Ejim L, Fiebig A, Yousefi Y , Coombes BK, Macneil L , Vazquez-Laslop N , Mankin AS, Wilson DN, Wright GD
(2026) Nature , 655 , 737 - 746
PUBMED: 42236948
DOI: doi:10.1038/s41586-026-10589-2
ISSN: 1476-4687
ASTM: NATUAS