EMD-53847
Cryo-EM structure of human ATP citrate lyase in complex with inhibitor EVT0185-CoA
EMD-53847
Single-particle3.25 Å
Deposition: 18/05/2025Map released: 04/03/2026
Last modified: 04/03/2026
Sample Organism:
Homo sapiens
Sample: Human ATP citrate lyase (homotetramer)
Fitted models: 9r90
Deposition Authors: Verstraete K
,
Verschueren K,
Savvides SN ,
Steinberg GR
Sample: Human ATP citrate lyase (homotetramer)
Fitted models: 9r90
Deposition Authors: Verstraete K
,
Verschueren K,
Savvides SN ,
Steinberg GR
ACLY inhibition promotes tumour immunity and suppresses liver cancer.
Gautam J,
Wu J ,
Lally JSV,
McNicol JD ,
Fayyazi R,
Ahmadi E ,
Oniciu DC,
Heaton S,
Newton RS,
Rehal S,
Bhattacharya D,
Di Pastena F,
Nguyen B ,
Valvano CM ,
Townsend LK ,
Banskota S ,
Batchuluun B,
Jabile MJT,
Payne A,
Lu J ,
Desjardins EM,
Kubota N,
Tsakiridis EE,
Mistry B,
Aganostopoulos A,
Houde V,
Dansercoer A,
Verschueren KHG,
Savvides SN ,
Hammill JA,
Bezverbnaya K,
Muti P,
Tsakiridis T ,
Dai W,
Jiang L ,
Hoshida Y ,
Larche M ,
Bramson JL ,
Friedman SL ,
Verstraete K ,
Wang D ,
Steinberg GR
(2025) Nature , 645 , 507 - 517
,
Lally JSV,
McNicol JD ,
Fayyazi R,
Ahmadi E ,
Oniciu DC,
Heaton S,
Newton RS,
Rehal S,
Bhattacharya D,
Di Pastena F,
Nguyen B ,
Valvano CM ,
Townsend LK ,
Banskota S ,
Batchuluun B,
Jabile MJT,
Payne A,
Lu J ,
Desjardins EM,
Kubota N,
Tsakiridis EE,
Mistry B,
Aganostopoulos A,
Houde V,
Dansercoer A,
Verschueren KHG,
Savvides SN ,
Hammill JA,
Bezverbnaya K,
Muti P,
Tsakiridis T ,
Dai W,
Jiang L ,
Hoshida Y ,
Larche M ,
Bramson JL ,
Friedman SL ,
Verstraete K ,
Wang D ,
Steinberg GR
(2025) Nature , 645 , 507 - 517
Grant Support:
- Research Foundation - Flanders (FWO): 1524918N (Belgium)