EMD-53322
Structure of the MMM ubiquitin ligase complex with nanobody 270 (Consensus map)
EMD-53322
Single-particle2.74 Å
Deposition: 04/04/2025Map released: 27/05/2026
Last modified: 27/05/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: Human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 270
Deposition Authors: Williams C
,
Carrique L ,
Pardon E ,
Nocka LM ,
Hedger G ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Rohatgi R ,
Siebold C
Sample: Human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 270
Deposition Authors: Williams C
,
Carrique L ,
Pardon E ,
Nocka LM ,
Hedger G ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Rohatgi R ,
Siebold C
Design principles of a membrane-tethered ubiquitin ligase
Williams C ,
Nocka LM ,
Hedger G ,
Carrique L ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Lartey D ,
Gao L ,
Pardon E ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Siebold C ,
Rohatgi R
(2026) Mol Cell
,
Nocka LM ,
Hedger G ,
Carrique L ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Lartey D ,
Gao L ,
Pardon E ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Siebold C ,
Rohatgi R
(2026) Mol Cell
Grant Support:
- Cancer Research UK: DRCRPG-May23/100002 (United Kingdom)
- Wellcome Trust: 218482/Z/19/Z (United Kingdom)
- Cancer Research UK: C20724/A26752 (United Kingdom)
- Wellcome Trust: 060208/Z/00/Z (United Kingdom)
- Wellcome Trust: 093305/Z/10/Z (United Kingdom)