EMD-53177

Single-particle
3.07 Å
EMD-53177
3D View Gallery
Deposition: 16/03/2025
Map released: 11/02/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53177

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9qhq summary report (pdf.gz) Map-9qhq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of mouse TRPM3 alpha 2 in with agonists CIM-0216 and Pregnenolone sulfate (PregS)

EMD-53177

Single-particle
3.07 Å
EMD-53177
3D View Gallery
Deposition: 16/03/2025
Map released: 11/02/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Tetrameric assembly of mouse TRPM3 alpha 2 with CIM-0216 and neurosteroid Pregnenolone sulfate (PregS)
Fitted models: 9qhq

Deposition Authors: Shkumatov AV , Schenck S , Brunner JD
Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3.
Bazeli B, Shkumatov AV , Schenck S , Vanherck JC, Janssens A, Spieser SAH, Marchand D, Roelens R, Chaltin P, Marchand A, Vriens J, Voets T, Brunner JD
(2026) Nat Commun , 17
PUBMED: 41922314
DOI: doi:10.1038/s41467-026-71226-0
ISSN: 2041-1723
Grant Support: