EMD-53004
Structure of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)
EMD-53004
Single-particle2.83 Å
Deposition: 04/03/2025Map released: 13/05/2026
Last modified: 22/07/2026
Sample Organism:
Homo sapiens
Sample: Complex of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)
Fitted models: 9qc6
Deposition Authors: Shilliday F
,
Maia de Oliveira T,
Gancedo-Rodrigo M
Sample: Complex of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)
Fitted models: 9qc6
Deposition Authors: Shilliday F
,
Maia de Oliveira T,
Gancedo-Rodrigo M
A molecular stabiliser of an inhibitory eIF2B-eIF2( alpha P) complex activates the Integrated Stress Response.
Shilliday F ,
Gancedo-Rodrigo M ,
George G,
Aibara S,
Adhikari S,
Ashraf SN,
Barrey EJ,
Centrella PA,
Crowther D ,
Dickson P ,
Gikunju D,
Guie MA,
Guilinger JP,
Gunnarsson A,
Harding HP ,
Hupp CD,
Jetson R,
Keefe AD ,
Kim JM,
Lewis RJ ,
Maia de Oliveira T,
Le-Marshall J,
Narayanan U,
Nugai KA,
Petrovic D ,
Rivers E,
Ron D ,
Stringfellow D ,
Syson K,
Ward L ,
Yeoman JTS,
Yu Y,
Zhang Y ,
Zyryanova A,
Baker DJ ,
Breccia P,
Linley JE
(2026) Nat Commun , 17
,
Gancedo-Rodrigo M ,
George G,
Aibara S,
Adhikari S,
Ashraf SN,
Barrey EJ,
Centrella PA,
Crowther D ,
Dickson P ,
Gikunju D,
Guie MA,
Guilinger JP,
Gunnarsson A,
Harding HP ,
Hupp CD,
Jetson R,
Keefe AD ,
Kim JM,
Lewis RJ ,
Maia de Oliveira T,
Le-Marshall J,
Narayanan U,
Nugai KA,
Petrovic D ,
Rivers E,
Ron D ,
Stringfellow D ,
Syson K,
Ward L ,
Yeoman JTS,
Yu Y,
Zhang Y ,
Zyryanova A,
Baker DJ ,
Breccia P,
Linley JE
(2026) Nat Commun , 17
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