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EMD-52997

Single-particle
3.8 Å
EMD-52997
3D View Gallery
Deposition: 02/03/2025
Map released: 06/08/2025
Last modified: 06/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52997
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9qbf summary report (pdf.gz) Map and 9qbf FULL report (pdf.gz)
EMICSS annotations (xml)

HER2/ErbB2 extracellular domain (ECD) in compact conformation in complex with trastuzumab (TZB) antibody

EMD-52997

Single-particle
3.8 Å
EMD-52997
3D View Gallery
Deposition: 02/03/2025
Map released: 06/08/2025
Last modified: 06/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Aequorea victoria
Sample: Ternary complex of HER2/ErbB2 in compact conformation with trastuzumab (TZB) antibody.
Fitted models: 9qbf

Deposition Authors: Gragera M , Buschiazzo A , Vacca S
Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation.
Vacca S , Gragera M , Buschiazzo A , Herreros D , Krieger JM , Bonn-Garcia S , Melero R , Sorzano CO, Carazo JM , Medalia O , Pluckthun A
(2025) Sci Adv , 11 , eadu9945 - eadu9945
PUBMED: 40712014
DOI: doi:10.1126/sciadv.adu9945
ISSN: 2375-2548