EMD-52978
The catalytic core with C2 symmetry of human telomerase dimer
EMD-52978
Single-particle3.3 Å
Deposition: 28/02/2025Map released: 16/07/2025
Last modified: 23/07/2025
Sample Organism:
Homo sapiens
Sample: The catalytic core with C2 symmetry of human telomerase dimer
Fitted models: 9qax
Deposition Authors: Balch S
,
Sekne Z ,
Franco-Echevarria E ,
Ludzia P ,
Kretsch RC ,
Sun W ,
Yu H ,
Ghanim GE ,
Sigurdur TR,
Ding Y ,
Das R ,
Nguyen THD
Sample: The catalytic core with C2 symmetry of human telomerase dimer
Fitted models: 9qax
Deposition Authors: Balch S
,
Sekne Z ,
Franco-Echevarria E ,
Ludzia P ,
Kretsch RC ,
Sun W ,
Yu H ,
Ghanim GE ,
Sigurdur TR,
Ding Y ,
Das R ,
Nguyen THD
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Balch S ,
Sekne Z ,
Franco-Echevarria E ,
Ludzia P ,
Kretsch RC ,
Sun W ,
Yu H ,
Ghanim GE ,
Thorkelsson S ,
Ding Y ,
Das R ,
Nguyen THD
(2025) Science , 389 , eadr5817 - eadr5817
,
Sekne Z ,
Franco-Echevarria E ,
Ludzia P ,
Kretsch RC ,
Sun W ,
Yu H ,
Ghanim GE ,
Thorkelsson S ,
Ding Y ,
Das R ,
Nguyen THD
(2025) Science , 389 , eadr5817 - eadr5817
Grant Support:
- UK Research and Innovation (UKRI): MC_UP_1201/19 (United Kingdom)
- Jane Coffin Childs (JCC) Fund: (United States)
- European Molecular Biology Organization (EMBO): (European Union)
- Wellcome Trust: 226015/Z/22/Z (United Kingdom)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 2R35GM122579 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)
- Chinese Scholarship Council: 202206620047 (China)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/X01102X/1 (United Kingdom)