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EMD-52968
Cryo-EM structure of the helicase core of ZNFX1
EMD-52968
Single-particle3.9 Å
Deposition: 27/02/2025Map released: 03/09/2025
Last modified: 29/10/2025
Sample Organism:
Homo sapiens
Sample: ZNFX1
Fitted models: 9q9z
Deposition Authors: Grabarczyk DB
,
Reznikow V,
Kurzbauer R,
Clausen T
Sample: ZNFX1
Fitted models: 9q9z
Deposition Authors: Grabarczyk DB
,
Reznikow V,
Kurzbauer R,
Clausen T
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
Grabarczyk DB ,
Aird EJ ,
Reznikow V,
Kirchgatterer PC,
Ehrmann JF,
Kurzbauer R,
Bell LE,
Kellner MJ,
Aggarwal R,
Schleiffer A,
Faas V,
Deszcz L,
Meinhart A,
Versteeg GA ,
Penninger JM,
Stelzl LS,
Gaidt MM,
Tessmer I,
Corn JE,
Clausen T
(2025) Cell , 188 , 5995
,
Aird EJ ,
Reznikow V,
Kirchgatterer PC,
Ehrmann JF,
Kurzbauer R,
Bell LE,
Kellner MJ,
Aggarwal R,
Schleiffer A,
Faas V,
Deszcz L,
Meinhart A,
Versteeg GA ,
Penninger JM,
Stelzl LS,
Gaidt MM,
Tessmer I,
Corn JE,
Clausen T
(2025) Cell , 188 , 5995
Grant Support:
- Austrian Research Promotion Agency: (Austria)
- H2020 Marie Curie Actions of the European Commission: (European Union)