EMD-52896
Cryo-EM structure of Shigella flexneri LptDE bound by a Bicyclic peptide molecule (Compound 16)
EMD-52896
Single-particle2.54 Å
Deposition: 25/02/2025Map released: 15/10/2025
Last modified: 05/11/2025
Sample Organism:
Shigella flexneri,
synthetic construct
Sample: Cryo-EM structure of S. flexneri LptDE complex bound by a Bicyclic peptide molecule (Compound 8)
Fitted models: 9q8n
Deposition Authors: Allyjaun S
,
Newman H ,
Chirgadze DY,
Hardwick SW,
Hubbard J,
van den Berg B,
Dunbar E
Sample: Cryo-EM structure of S. flexneri LptDE complex bound by a Bicyclic peptide molecule (Compound 8)
Fitted models: 9q8n
Deposition Authors: Allyjaun S
,
Newman H ,
Chirgadze DY,
Hardwick SW,
Hubbard J,
van den Berg B,
Dunbar E
High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM.
Allyjaun S ,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
Grant Support:
- Innovate UK: 10086683 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): U-016275 IAA-CiC (United Kingdom)