EMD-52823
Chimeric mitochondrial DNA polymerase gamma ternary complex (mAhB) in mouse-like error-editing conformer (composite)
EMD-52823
Single-particle3.24 Å
Deposition: 14/02/2025Map released: 04/06/2025
Last modified: 04/06/2025
Sample Organism:
Mus musculus,
Homo sapiens,
synthetic construct
Sample: Chimeric mitochondrial DNA polymerase gamma ternary complex (mAhB) in mouse-like error-editing conformer (composite)
Fitted models: 9ic0
Deposition Authors: Valenzuela S
,
Falkenberg M
Sample: Chimeric mitochondrial DNA polymerase gamma ternary complex (mAhB) in mouse-like error-editing conformer (composite)
Fitted models: 9ic0
Deposition Authors: Valenzuela S
,
Falkenberg M
Modelling POLG mutations in mice unravels a critical role of POL gamma Beta in regulating phenotypic severity.
Corra S,
Zuppardo A ,
Valenzuela S ,
Jenninger L,
Cerutti R,
Sillamaa S ,
Hoberg E,
Johansson KAS ,
Rovsnik U ,
Volta S,
Silva-Pinheiro P ,
Davis H,
Trifunovic A ,
Minczuk M ,
Gustafsson CM ,
Suomalainen A ,
Zeviani M,
Macao B ,
Zhu X ,
Falkenberg M ,
Viscomi C
(2025) Nat Commun , 16 , 4782 - 4782
,
Valenzuela S ,
Jenninger L,
Cerutti R,
Sillamaa S ,
Hoberg E,
Johansson KAS ,
Rovsnik U ,
Volta S,
Silva-Pinheiro P ,
Davis H,
Trifunovic A ,
Minczuk M ,
Gustafsson CM ,
Suomalainen A ,
Zeviani M,
Macao B ,
Zhu X ,
Falkenberg M ,
Viscomi C
(2025) Nat Commun , 16 , 4782 - 4782
Grant Support:
- Swedish Research Council: (Sweden)
- Cancerfonden: (Sweden)
- Knut and Alice Wallenberg Foundation: (Sweden)