EMD-52566

Single-particle
3.1 Å
EMD-52566
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Deposition: 16/01/2025
Map released: 28/01/2026
Last modified: 28/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52566
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Local Refinement of human M4 muscarinic acetylcholine receptor G protein complex bound to selective PAM Emraclidine

EMD-52566

Single-particle
3.1 Å
EMD-52566
3D View Gallery
Deposition: 16/01/2025
Map released: 28/01/2026
Last modified: 28/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: M4 mAChR bound to PAM Emraclidine in complex with dominant negative Galpha-il, Gbetal, Gamma2, and scFv16

Deposition Authors: Trabuco M , Sawicka M , Botte M , Vacca S

The Distinct Pharmacological Profile of Emraclidine, a Selective Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor
Pin S, Wonsey-Quinn A, Trabuco M , Toh MF, Te L, Klein E, Catipay G, Smith DL, Gupta K, Hatch J, Nguyen H, Iredale P
To Be Published
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