EMD-52458
In vitro grown K58N Alpha-Synuclein Fibrils
EMD-52458
Single-particle3.7 Å
Deposition: 07/01/2025Map released: 12/02/2025
Last modified: 29/07/2026
Sample Organism:
Homo sapiens
Sample: Alpha-Synuclein K58N
Fitted models: 9hxa
Deposition Authors: Sicking K, Al-Azzani M
,
Outeiro TF,
Fernandez-Busnadiego R
Sample: Alpha-Synuclein K58N
Fitted models: 9hxa
Deposition Authors: Sicking K, Al-Azzani M
,
Outeiro TF,
Fernandez-Busnadiego R
A Novel alpha-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.
Al-Azzani M ,
Weber S ,
Ramalingam N ,
Ramon M,
Shvachiy L,
Mestre G,
Zech M ,
Sicking K,
de Opakua AI,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Fernandez-Busnadiego R ,
Mollenhauer B ,
Outeiro TF
(2025) Mov Disord , 40 , 2732 - 2745
,
Weber S ,
Ramalingam N ,
Ramon M,
Shvachiy L,
Mestre G,
Zech M ,
Sicking K,
de Opakua AI,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Fernandez-Busnadiego R ,
Mollenhauer B ,
Outeiro TF
(2025) Mov Disord , 40 , 2732 - 2745
Grant Support:
- German Research Foundation (DFG): EXC 2067/1-390729940 (Germany)
- German Research Foundation (DFG): SFB1286 (B8) (Germany)
- German Research Foundation (DFG): SFB1286 (A12) (Germany)
- German Research Foundation (DFG): 448415290 (Germany)
- Michael J. Fox Foundation: ASAP-000282 (United States)