EMD-52416

Single-particle
3.35 Å
EMD-52416
3D View Gallery
Deposition: 23/12/2024
Map released: 14/01/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52416

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9hum summary report (pdf.gz) Map-9hum FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after short GABA treatment

EMD-52416

Single-particle
3.35 Å
EMD-52416
3D View Gallery
Deposition: 23/12/2024
Map released: 14/01/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Aequorea victoria, Escherichia coli
Sample: heteromeric assembly in 2 a5 to 3 b3 ratio bound to 1 Mb25
Fitted models: 9hum

Deposition Authors: Cowgill J , Fan C , Howard RJ , Lindahl E
Structural basis for activation and potentiation in a human alpha 5 beta 3 GABA A receptor.
Cowgill J , Fan C , Steyaert J, Howard RJ , Lindahl E
(2026) Nat Commun , 17
PUBMED: 42297817
DOI: doi:10.1038/s41467-026-74279-3
ISSN: 2041-1723