EMD-52330

Single-particle
2.93 Å
EMD-52330
3D View Gallery
Deposition: 13/12/2024
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52330

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9hpi summary report (pdf.gz) Map-9hpi FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of DDB1dB-CRBN-MRT-0031619, conformation 1

EMD-52330

Single-particle
2.93 Å
EMD-52330
3D View Gallery
Deposition: 13/12/2024
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Drug-induced ternary complex between two DDB1-CRBN moieties
Fitted models: 9hpi

Deposition Authors: Langousis G, Hunkeler M , Chami M, Quan C , Townson S, Bonenfant D
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.
Langousis G, Gainza P , Hunkeler M , Kapsitidou D, Donckele EJ, Annunziato S, Wiedmer L, Jones KFM, DeMarco B, Quan C , Bunker RD , Lumb KJ , Fasching B, Castle JC, Townson SA , Bonenfant D
(2025) Nat Commun , 16 , 10157 - 10157
PUBMED: 41258141
DOI: doi:10.1038/s41467-025-65094-3
ISSN: 2041-1723
Grant Support: