EMD-52275

Single-particle
3.8 Å
EMD-52275
3D View Gallery
Deposition: 05/12/2024
Map released: 17/12/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52275

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9hlx summary report (pdf.gz) Map-9hlx FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of Ba1Cas12a3 binary complex

EMD-52275

Single-particle
3.8 Å
EMD-52275
3D View Gallery
Deposition: 05/12/2024
Map released: 17/12/2025
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Bacteroidetes bacterium HGW-Bacteroidetes-12, Bacteroidota bacterium, synthetic construct
Sample: Ba1Cas12a3 binary complex
Fitted models: 9hlx

Deposition Authors: Yuan B, Heinz DW
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity.
Dmytrenko O, Yuan B, Crosby KT, Krebel M, Chen X, Nowak JS, Chramiec-Glabik A, Filani B, Gribling-Burrer AS, van der Toorn W, von Kleist M, Achmedov T, Smyth RP, Glatt S, Bravo JPK, Heinz DW, Jackson RN, Beisel CL
(2026) Nature , 649 , 1312 - 1321
PUBMED: 41501459
DOI: doi:10.1038/s41586-025-09852-9
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: