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EMD-52243
TRPML1 in complex with compound 3
EMD-52243
Single-particle2.1 Å
Deposition: 04/12/2024Map released: 04/06/2025
Last modified: 17/12/2025
Sample Organism:
Homo sapiens
Sample: Mucolipin-1
Fitted models: 9hl4
Deposition Authors: Reeks J
,
Mahajan P,
Clark M,
Cowan SR,
Di Daniel E,
Earl CP,
Fisher S,
Holvey RS,
Jackson SM,
Lloyd-Evans E,
Morgillo CM,
Mortenson PN,
O'Reilly M,
Richardson CJ,
Schopf P,
Tams DM,
Waller-Evans H,
Ward SE,
Whibley S,
Williams PA,
Johnson CN
Sample: Mucolipin-1
Fitted models: 9hl4
Deposition Authors: Reeks J
,
Mahajan P,
Clark M,
Cowan SR,
Di Daniel E,
Earl CP,
Fisher S,
Holvey RS,
Jackson SM,
Lloyd-Evans E,
Morgillo CM,
Mortenson PN,
O'Reilly M,
Richardson CJ,
Schopf P,
Tams DM,
Waller-Evans H,
Ward SE,
Whibley S,
Williams PA,
Johnson CN
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Reeks J ,
Mahajan P,
Clark M,
Cowan SR,
Di Daniel E,
Earl CP,
Fisher S,
Holvey RS,
Jackson SM,
Lloyd-Evans E,
Morgillo CM,
Mortenson PN,
O'Reilly M,
Richardson CJ,
Schopf P,
Tams DM,
Waller-Evans H,
Ward SE,
Whibley S,
Williams PA,
Johnson CN
(2025) Structure , 33 , 1374 - 1385.e7
,
Mahajan P,
Clark M,
Cowan SR,
Di Daniel E,
Earl CP,
Fisher S,
Holvey RS,
Jackson SM,
Lloyd-Evans E,
Morgillo CM,
Mortenson PN,
O'Reilly M,
Richardson CJ,
Schopf P,
Tams DM,
Waller-Evans H,
Ward SE,
Whibley S,
Williams PA,
Johnson CN
(2025) Structure , 33 , 1374 - 1385.e7
Grant Support: