EMD-52224

Single-particle
3.8 Å
EMD-52224
3D View Gallery
Deposition: 30/11/2024
Map released: 17/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52224

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9hjq summary report (pdf.gz) Map-9hjq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

ROCK2 bound with TDI01

EMD-52224

Single-particle
3.8 Å
EMD-52224
3D View Gallery
Deposition: 30/11/2024
Map released: 17/06/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Rho-associated protein kinase 2 bound with inhibitor TDI01
Fitted models: 9hjq

Deposition Authors: Aijia W, Shenghai C, Qinghua L, Yan H, Haohao D, Bisen D
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis.
Hu Y, Yang B, Xiao C, Yang X, Zhang H, Yang P, Du X, Zhang G, Liang B, Bai N, Zhang D, Wu D, Luo Q, Teng Y, Chen Y, Guo Z, Zhao C, Ye T, Chai D, Qi X, Zhong W, Chen J, Dong H, Gao J, He H, Chang J, Li X, Peng L, Rafii S, Friedman SL, Yi C, Cai Y, Zhao Y, Wang H, Wang C, Cao Z, Ding BS
(2026) Cell , 189 , 2663 - 2683.e26
PUBMED: 41794026
DOI: doi:10.1016/j.cell.2026.02.001
ISSN: 1097-4172