Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-52213

Single-particle
3.35 Å
EMD-52213
3D View Gallery
Deposition: 28/11/2024
Map released: 30/07/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52213
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9hjd summary report (pdf.gz) Map and 9hjd FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of domperidone-bound human SLC19A3 in inward-open state

EMD-52213

Single-particle
3.35 Å
EMD-52213
3D View Gallery
Deposition: 28/11/2024
Map released: 30/07/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: hSLC19A3:Nb3.3:domperidone
Fitted models: 9hjd

Deposition Authors: Gabriel F , Loew C
Structure-based discovery of thiamine uptake inhibitors.
Gabriel F , Windshugel B , Low C
(2025) Br.J.Pharmacol. , 182 , 5611 - 5626
PUBMED: 40702645
DOI: doi:10.1111/bph.70133
ISSN: 0007-1188
ASTM: BJPCBH
Grant Support: