EMD-52207

Single-particle
2.6 Å
EMD-52207
3D View Gallery
Deposition: 27/11/2024
Map released: 20/08/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52207

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9hj0 summary report (pdf.gz) Map-9hj0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib

EMD-52207

Single-particle
2.6 Å
EMD-52207
3D View Gallery
Deposition: 27/11/2024
Map released: 20/08/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CDK-activating kinase (CAK)
Fitted models: 9hj0

Deposition Authors: Cushing VI , Greber BJ , Ali S , Lai C-F , Bevan CL , Coombes RC , Buluwela L

Mutation of CDK7 at a conserved residue identifies a common mechanism of acquired resistance to CDK inhibitors in cancer
Lai C-F , Cushing VI , Bevan CL , Coombes RC , Greber BJ , Buluwela L, Ali S
To Be Published