EMD-52166
In vitro grown G14R Alpha-Synuclein Fibrils
EMD-52166
Single-particle3.0 Å
Deposition: 20/11/2024Map released: 29/01/2025
Last modified: 29/07/2026
Sample Organism:
Homo sapiens
Sample: Alpha-Synuclein G14R
Fitted models: 9hgs
Deposition Authors: Sicking K, Fernandez-Busnadiego R
Sample: Alpha-Synuclein G14R
Fitted models: 9hgs
Deposition Authors: Sicking K, Fernandez-Busnadiego R
A Novel alpha-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease.
Al-Azzani M ,
Weber S,
Ramalingam N,
Ramon M,
Shvachiy L,
Mestre G,
Zech M,
Sicking K,
de Opakua AI,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR ,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Fernandez-Busnadiego R ,
Mollenhauer B,
Outeiro TF
(2025) Mov Disord , 40 , 2732 - 2745
,
Weber S,
Ramalingam N,
Ramon M,
Shvachiy L,
Mestre G,
Zech M,
Sicking K,
de Opakua AI,
Jayanthi V,
Amaral L,
Agarwal A,
Chandran A,
Chaves SR ,
Winkelmann J,
Trenkwalder C,
Schwager M,
Pauli S,
Dettmer U,
Fernandez CO,
Lautenschlager J,
Zweckstetter M,
Fernandez-Busnadiego R ,
Mollenhauer B,
Outeiro TF
(2025) Mov Disord , 40 , 2732 - 2745
Secondary citations:
- Al-Azzani M, Weber S, Ramalingam N, Ramon M, Shvachiy L, Mestre G, Zech M, Sicking K, Ibanez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernandez CO, Lautenschlager J, Zweckstetter M, Busnadiego RF, Mollenhauer B & Outeiro TF. (2025) A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease.
- Brucke C, Al-Azzani M, Ramalingam N, Ramon M, Sousa RL, Buratti F, Zech M, Sicking K, Amaral L, Gelpi E, Chandran A, Agarwal A, Chaves SR, Fernandez CO, Dettmer U, Lautenschlager J, Zweckstetter M, Busnadiego RF, Zimprich A & Outeiro TF. (2024) A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features.
Grant Support:
- German Research Foundation (DFG): EXC 2067/1-390729940 (Germany)
- German Research Foundation (DFG): SFB1286 (B8) (Germany)
- German Research Foundation (DFG): SFB1286 (A12) (Germany)
- German Research Foundation (DFG): 448415290 (Germany)
- Michael J. Fox Foundation: ASAP-000282 (United States)