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EMD-52012
cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A)
EMD-52012
Composite mapSingle-particle
2.5 Å
Deposition: 05/11/2024Map released: 04/06/2025
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Dendroaspis angusticeps
Sample: Inactive V2R-bril bound to tolvaptan stabillized with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9hb3
Deposition Authors: Bous J
,
Fouillen A ,
Couvineau P ,
Orcel H ,
Mary C,
Mendre C ,
Schulte G ,
Granier S ,
Gilles N ,
Mouillac B
Sample: Inactive V2R-bril bound to tolvaptan stabillized with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9hb3
Deposition Authors: Bous J
,
Fouillen A ,
Couvineau P ,
Orcel H ,
Mary C,
Mendre C ,
Schulte G ,
Granier S ,
Gilles N ,
Mouillac B
Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.
Fouillen A ,
Bous J ,
Couvineau P ,
Orcel H ,
Mary C,
Lafleur L,
Pierre T,
Mendre C ,
Gilles N ,
Schulte G ,
Granier S ,
Mouillac B
(2025) Nat Commun , 16 , 3899 - 3899
,
Bous J ,
Couvineau P ,
Orcel H ,
Mary C,
Lafleur L,
Pierre T,
Mendre C ,
Gilles N ,
Schulte G ,
Granier S ,
Mouillac B
(2025) Nat Commun , 16 , 3899 - 3899
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