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EMD-51963
Cryo-EM structure of the human GABAA receptor alpha1 subunit in complex with the assembly factor NACHO/TMEM35A
EMD-51963
Single-particle3.6 Å
Deposition: 30/10/2024Map released: 04/12/2024
Last modified: 04/12/2024
Sample Organism:
Homo sapiens
Sample: Complex of Gamma-aminobutyric acid receptor subunit alpha-1 with assembly factor NACHO/TMEM35A
Fitted models: 9h9e
Deposition Authors: Hooda Y
,
Sente A
,
Judy RM
,
Smalinskaite L
,
Peak-Chew S,
Naydenova K
,
Malinauskas T
,
Hardwick SW
,
Chirgadze DY
,
Aricescu AR
,
Hegde RS
Sample: Complex of Gamma-aminobutyric acid receptor subunit alpha-1 with assembly factor NACHO/TMEM35A
Fitted models: 9h9e
Deposition Authors: Hooda Y
,
Sente A
,
Judy RM
,
Smalinskaite L
,
Peak-Chew S,
Naydenova K
,
Malinauskas T
,
Hardwick SW
,
Chirgadze DY
,
Aricescu AR
,
Hegde RS
Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels.
Hooda Y
,
Sente A
,
Judy RM
,
Smalinskaite L
,
Chew SP,
Naydenova K
,
Malinauskas T
,
Hardwick SW
,
Chirgadze DY
,
Aricescu AR
,
Hegde RS
(2024) bioRxiv
,
Sente A
,
Judy RM
,
Smalinskaite L
,
Chew SP,
Naydenova K
,
Malinauskas T
,
Hardwick SW
,
Chirgadze DY
,
Aricescu AR
,
Hegde RS
(2024) bioRxiv
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_ A022_1007 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/15 (United Kingdom)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 1R01GM135550-01 (United States)
- Medical Research Council (MRC, United Kingdom): MC_EX_MR/T046279/1 (United Kingdom)
- National Science Foundation (NSF, United States): 2014862 (United States)
