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EMD-51737
WT-IAPP cryo-EM structure Type LLUU, doxazosin reaction
EMD-51737
Helical reconstruction3.0 Å
Deposition: 04/10/2024Map released: 05/03/2025
Last modified: 16/04/2025
Sample Organism:
synthetic construct,
Homo sapiens
Sample: Amyloid fibril with helical symmetry
Fitted models: 9gzy
Deposition Authors: Wilkinson M, Taylor AIP
,
Xu Y,
Chakraborty P ,
Brinkworth A,
Willis LF,
Zhuravleva A ,
Ranson NA,
Foster R ,
Radford SE
Sample: Amyloid fibril with helical symmetry
Fitted models: 9gzy
Deposition Authors: Wilkinson M, Taylor AIP
,
Xu Y,
Chakraborty P ,
Brinkworth A,
Willis LF,
Zhuravleva A ,
Ranson NA,
Foster R ,
Radford SE
Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
Taylor AIP ,
Xu Y,
Wilkinson M,
Chakraborty P ,
Brinkworth A,
Willis LF,
Zhuravleva A ,
Ranson NA,
Foster R ,
Radford SE
(2025) J Am Chem Soc , 147 , 11859 - 11878
,
Xu Y,
Wilkinson M,
Chakraborty P ,
Brinkworth A,
Willis LF,
Zhuravleva A ,
Ranson NA,
Foster R ,
Radford SE
(2025) J Am Chem Soc , 147 , 11859 - 11878
Grant Support:
- Wellcome Trust: 204963 (United Kingdom)
- Royal Society: RSRP/R1/211057 (United Kingdom)