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EMD-51680

Single-particle
3.42 Å
EMD-51680
3D View Gallery
Deposition: 01/10/2024
Map released: 29/01/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51680
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9gy0 summary report (pdf.gz) Map and 9gy0 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo_EM structure of human FAN1 R507H mutant in complex with 5' flap DNA substrate and PCNA

EMD-51680

Single-particle
3.42 Å
EMD-51680
3D View Gallery
Deposition: 01/10/2024
Map released: 29/01/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of FAN1 R507H-PCNA-DNA
Fitted models: 9gy0

Deposition Authors: Jeyasankar G , Salerno-Kochan A , Thomsen M
A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA.
Aretz J , Jeyasankar G , Salerno-Kochan A , Thomsen M, Thieulin-Pardo G, Haque T , Monteagudo E, Felsenfeld D, Finley M , Vogt TF, Boudet J , Prasad BC
(2025) Nat Commun , 16 , 4412 - 4412
PUBMED: 40368883
DOI: doi:10.1038/s41467-025-59324-x
ISSN: 2041-1723
Grant Support: