EMD-51524

Single-particle
3.9 Å
EMD-51524
3D View Gallery
Deposition: 13/09/2024
Map released: 04/12/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51524

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Maps from particle subsets of methylamine treated human complement C3 showing three distinct ANA positions

EMD-51524

Single-particle
3.9 Å
EMD-51524
3D View Gallery
Deposition: 13/09/2024
Map released: 04/12/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: methylamine treated complement C3 in complex with a nanobody enabling dimer formation

Deposition Authors: Joergensen MH , Andersen GR
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.
Gadeberg TAF, Jorgensen MH , Olesen HG, Lorentzen J , Harwood SL, Almeida AV, Fruergaard MU, Jensen RK , Kanis P , Pedersen H, Tranchant E , Petersen SV, Thogersen IB, Kragelund BB , Lyons JA , Enghild JJ , Andersen GR
(2025) Nat Struct Mol Biol , 32 , 884 - 895
PUBMED: 39849196
DOI: doi:10.1038/s41594-024-01467-4
ISSN: 1545-9985