Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-51434
Befiradol-bound serotonin 5-HT1A receptor - Gs Protein Complex
EMD-51434
Single-particle3.2 Å
Deposition: 26/08/2024Map released: 02/07/2025
Last modified: 09/07/2025
Sample Organism:
Homo sapiens
Sample: Tern
Fitted models: 9gl2
Deposition Authors: Schneider J
,
Gmeiner P ,
Boettcher B ,
Rasmussen T
Sample: Tern
Fitted models: 9gl2
Deposition Authors: Schneider J
,
Gmeiner P ,
Boettcher B ,
Rasmussen T
Discovery of a functionally selective serotonin receptor (5-HT 1A R) agonist for the treatment of pain.
Ullrich A ,
Schneider J ,
Braz JM ,
Neu E ,
Staffen N,
Stanek M,
Blahova J ,
Hove T ,
Albert T,
Allikalt A ,
Lober S,
Bhardwaj K ,
Rodriguez-Rosado S ,
Fink E,
Rasmussen T ,
Hubner H ,
Inoue A ,
Shoichet BK ,
Basbaum AI ,
Bottcher B,
Weikert D ,
Gmeiner P
(2025) Sci Adv , 11 , eadv9267 - eadv9267
,
Schneider J ,
Braz JM ,
Neu E ,
Staffen N,
Stanek M,
Blahova J ,
Hove T ,
Albert T,
Allikalt A ,
Lober S,
Bhardwaj K ,
Rodriguez-Rosado S ,
Fink E,
Rasmussen T ,
Hubner H ,
Inoue A ,
Shoichet BK ,
Basbaum AI ,
Bottcher B,
Weikert D ,
Gmeiner P
(2025) Sci Adv , 11 , eadv9267 - eadv9267
Grant Support:
- German Research Foundation (DFG): 359471283 (Germany)
- German Research Foundation (DFG): 456578072 (Germany)
- German Research Foundation (DFG): 525040890 (Germany)