EMD-51379

Single-particle
3.92 Å
EMD-51379
3D View Gallery
Deposition: 19/08/2024
Map released: 07/05/2025
Last modified: 07/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51379

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9giw summary report (pdf.gz) Map-9giw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the human mitochondrial pyruvate carrier inhibited by zaprinast

EMD-51379

Single-particle
3.92 Å
EMD-51379
3D View Gallery
Deposition: 19/08/2024
Map released: 07/05/2025
Last modified: 07/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Complex of human mitochondrial pyruvate carrier (MPC1L/MPC2) inhibited by zaprinast with a pro-macrobody
Fitted models: 9giw

Deposition Authors: Sichrovsky M , Lacabanne D, Ruprecht JJ , Rana JJ , Stanik K , Dionysopoulou M , Sowton AP , King MS , Jones S, Cooper L , Hardwick SW , Paris G , Chirgadze DY , Ding S, Fearnley IM , Palmer S, Pardon E , Steyaert J , Leone V , Forrest LR , Tavoulari S , Kunji ERS
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sichrovsky M , Lacabanne D, Ruprecht JJ , Rana JJ , Stanik K , Dionysopoulou M , Sowton AP , King MS , Jones SA , Cooper L , Hardwick SW , Paris G , Chirgadze DY , Ding S, Fearnley IM , Palmer SM, Pardon E , Steyaert J , Leone V , Forrest LR , Tavoulari S , Kunji ERS
(2025) Sci Adv , 11 , eadw1489 - eadw1489
PUBMED: 40249800
DOI: doi:10.1126/sciadv.adw1489
ISSN: 2375-2548