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EMD-51378
Structure of the human mitochondrial pyruvate carrier inhibited by a UK5099-derivative
EMD-51378
Single-particle3.65 Å
Deposition: 19/08/2024Map released: 07/05/2025
Last modified: 07/05/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of human mitochondrial pyruvate carrier (MPC1L/MPC2) inhibited by a UK5099-derivative with a pro-macrobody
Fitted models: 9giv
Deposition Authors: Sichrovsky M
,
Lacabanne D,
Ruprecht JJ ,
Rana JJ ,
Stanik K ,
Dionysopoulou M ,
Sowton AP ,
King MS ,
Jones S,
Cooper L ,
Hardwick SW ,
Paris G ,
Chirgadze DY ,
Ding S,
Fearnley IMF,
Palmer S,
Pardon E ,
Steyaert J ,
Leone V ,
Forrest LR ,
Tavoulari S ,
Kunji ERS
Sample: Complex of human mitochondrial pyruvate carrier (MPC1L/MPC2) inhibited by a UK5099-derivative with a pro-macrobody
Fitted models: 9giv
Deposition Authors: Sichrovsky M
,
Lacabanne D,
Ruprecht JJ ,
Rana JJ ,
Stanik K ,
Dionysopoulou M ,
Sowton AP ,
King MS ,
Jones S,
Cooper L ,
Hardwick SW ,
Paris G ,
Chirgadze DY ,
Ding S,
Fearnley IMF,
Palmer S,
Pardon E ,
Steyaert J ,
Leone V ,
Forrest LR ,
Tavoulari S ,
Kunji ERS
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier.
Sichrovsky M ,
Lacabanne D,
Ruprecht JJ ,
Rana JJ ,
Stanik K ,
Dionysopoulou M ,
Sowton AP ,
King MS ,
Jones SA ,
Cooper L ,
Hardwick SW ,
Paris G ,
Chirgadze DY ,
Ding S,
Fearnley IM ,
Palmer SM,
Pardon E ,
Steyaert J ,
Leone V ,
Forrest LR ,
Tavoulari S ,
Kunji ERS
(2025) Sci Adv , 11 , eadw1489 - eadw1489
,
Lacabanne D,
Ruprecht JJ ,
Rana JJ ,
Stanik K ,
Dionysopoulou M ,
Sowton AP ,
King MS ,
Jones SA ,
Cooper L ,
Hardwick SW ,
Paris G ,
Chirgadze DY ,
Ding S,
Fearnley IM ,
Palmer SM,
Pardon E ,
Steyaert J ,
Leone V ,
Forrest LR ,
Tavoulari S ,
Kunji ERS
(2025) Sci Adv , 11 , eadw1489 - eadw1489
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UU_00028/2 (United Kingdom)
- European Union (EU): Instruct-ERIC part of the European Strategy Forum on Research infrastructures (ESFRI) (PID: 22183) (European Union)
- Research Foundation - Flanders (FWO): (Belgium)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NS003139 (United States)