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EMD-51337

Single-particle
2.71 Å
EMD-51337
3D View Gallery
Deposition: 13/08/2024
Map released: 09/04/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51337
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ggm summary report (pdf.gz) Map and 9ggm FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of KBTBD4 P313PRR mutant-HDAC2 2:2 complex

EMD-51337

Single-particle
2.71 Å
EMD-51337
3D View Gallery
Deposition: 13/08/2024
Map released: 09/04/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: KBTBD4 R313PRR cancer mutant in complex with HDAC2 at 2:2 stoichiometry
Fitted models: 9ggm

Deposition Authors: Chen Z , Chi G , Pike ACW, Montes B, Bullock AN
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Chen Z , Chi G , Balo T , Chen X , Montes BR, Clifford SC , D'Angiolella V , Szabo T , Kiss A, Novak T, Herner A , Kotschy A, Bullock AN
(2025) Nat Commun , 16 , 3144 - 3144
PUBMED: 40175372
DOI: doi:10.1038/s41467-025-58350-z
ISSN: 2041-1723
Grant Support: