EMD-51336

Single-particle
3.3 Å
EMD-51336
3D View Gallery
Deposition: 13/08/2024
Map released: 09/04/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51336

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM map of KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171

EMD-51336

Single-particle
3.3 Å
EMD-51336
3D View Gallery
Deposition: 13/08/2024
Map released: 09/04/2025
Last modified: 09/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171

Deposition Authors: Chen Z , Chi G , Pike ACW , Montes B , Bullock AN
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Chen Z , Chi G , Balo T , Chen X , Montes BR, Clifford SC , D'Angiolella V , Szabo T , Kiss A, Novak T, Herner A , Kotschy A, Bullock AN
(2025) Nat Commun , 16 , 3144 - 3144
PUBMED: 40175372
DOI: doi:10.1038/s41467-025-58350-z
ISSN: 2041-1723
Grant Support: