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EMD-51336
Cryo-EM map of KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171
EMD-51336
Single-particle3.3 Å
Deposition: 13/08/2024Map released: 09/04/2025
Last modified: 09/04/2025
Sample Organism:
Homo sapiens
Sample: KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171
Deposition Authors: Chen Z
,
Chi G ,
Pike ACW ,
Montes B ,
Bullock AN
Sample: KBTBD4 WT-HDAC2-CoREST1 2:1:1 complex mediated by molecular glue UM171
Deposition Authors: Chen Z
,
Chi G ,
Pike ACW ,
Montes B ,
Bullock AN
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Chen Z ,
Chi G ,
Balo T ,
Chen X ,
Montes BR,
Clifford SC ,
D'Angiolella V ,
Szabo T ,
Kiss A,
Novak T,
Herner A ,
Kotschy A,
Bullock AN
(2025) Nat Commun , 16 , 3144 - 3144
,
Chi G ,
Balo T ,
Chen X ,
Montes BR,
Clifford SC ,
D'Angiolella V ,
Szabo T ,
Kiss A,
Novak T,
Herner A ,
Kotschy A,
Bullock AN
(2025) Nat Commun , 16 , 3144 - 3144
Grant Support:
- Cancer Research UK: DRCNPG-May21/100002 (United Kingdom)
- Innovative Medicines Initiative: 875510 (Switzerland)