Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-51326
Structure of the G848S mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
EMD-51326
Single-particle2.63 Å
Deposition: 13/08/2024Map released: 16/04/2025
Last modified: 09/07/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Structure of the G848S mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
Fitted models: 9ggb
Deposition Authors: Valenzuela S
,
Falkenberg M
Sample: Structure of the G848S mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
Fitted models: 9ggb
Deposition Authors: Valenzuela S
,
Falkenberg M
Small molecules restore mutant mitochondrial DNA polymerase activity.
Valenzuela S ,
Zhu X,
Macao B,
Stamgren M,
Geukens C,
Charifson PS,
Kern G,
Hoberg E,
Jenninger L,
Gruszczyk AV ,
Lee S,
Johansson KAS ,
Miralles Fuste J ,
Shi Y,
Kerns SJ,
Arabanian L,
Martinez Botella G,
Ekstrom S,
Green J ,
Griffin AM,
Pardo-Hernandez C,
Keating TA ,
Kuppers-Munther B,
Larsson NG ,
Phan C,
Posse V ,
Jones JE,
Xie X,
Giroux S ,
Gustafsson CM ,
Falkenberg M
(2025) Nature , 642 , 501 - 507
,
Zhu X,
Macao B,
Stamgren M,
Geukens C,
Charifson PS,
Kern G,
Hoberg E,
Jenninger L,
Gruszczyk AV ,
Lee S,
Johansson KAS ,
Miralles Fuste J ,
Shi Y,
Kerns SJ,
Arabanian L,
Martinez Botella G,
Ekstrom S,
Green J ,
Griffin AM,
Pardo-Hernandez C,
Keating TA ,
Kuppers-Munther B,
Larsson NG ,
Phan C,
Posse V ,
Jones JE,
Xie X,
Giroux S ,
Gustafsson CM ,
Falkenberg M
(2025) Nature , 642 , 501 - 507
Grant Support:
- Swedish Research Council: (Sweden)
- Knut and Alice Wallenberg Foundation: (Sweden)
- Cancerfonden: (Sweden)