Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-50888
Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
EMD-50888
Helical reconstruction2.23 Å
Deposition: 03/07/2024Map released: 17/07/2024
Last modified: 22/01/2025
Sample Organism:
Homo sapiens
Sample: alpha-synuclein amyloid fibril
Fitted models: 9fyp
Deposition Authors: Frey L, Qureshi BM, Kwiatkowski W, Rhyner D, Greenwald J
,
Riek R
Sample: alpha-synuclein amyloid fibril
Fitted models: 9fyp
Deposition Authors: Frey L, Qureshi BM, Kwiatkowski W, Rhyner D, Greenwald J
,
Riek R
On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Frey L,
Ghosh D,
Qureshi BM,
Rhyner D,
Guerrero-Ferreira R,
Pokharna A ,
Kwiatkowski W,
Serdiuk T,
Picotti P ,
Riek R,
Greenwald J
(2024) eLife , 12
,
Kwiatkowski W,
Serdiuk T,
Picotti P ,
Riek R,
Greenwald J
(2024) eLife , 12
Secondary citations:
- Frey L, Ghosh D, Qureshi BM, Rhyner D, Guerrero-Ferreira R, Pokharna A, Kwiatkowski W, Serdiuk T, Picotti P, Riek R & Greenwald J. (2024) On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation. eLife, 12,
- Frey L, Ghosh D, Qureshi BM, Rhyner D, Guerrero-Ferreira R, Pokharna A, Kwiatkowski W, Serdiuk T, Picotti P, Riek R & Greenwald J. (2024) On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation. eLife,
Grant Support:
- Swiss National Science Foundation: (Switzerland)
- Other government: