EMD-50502
Lysosomal transporting complex of beta-glucocerebrosidase (GCase) and lysosomal integral membrane protein 2 (LIMP-2) with bound Pro-macrobodies (Combined focus map)
EMD-50502
Single-particle3.7 Å
Deposition: 31/05/2024Map released: 09/04/2025
Last modified: 09/04/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Lysosomal transporting complex of beta-glucocerebrosidase and lysosomal integral membrane protein 2 (LIMP-2) with two bound Pro-macrobodies.
Fitted models: 9fjf
Deposition Authors: Dobert JP, Schaefer JHS, Dal Maso T
,
Socher E ,
Versees W ,
Moeller A ,
Zunke F ,
Arnold P
Sample: Lysosomal transporting complex of beta-glucocerebrosidase and lysosomal integral membrane protein 2 (LIMP-2) with two bound Pro-macrobodies.
Fitted models: 9fjf
Deposition Authors: Dobert JP, Schaefer JHS, Dal Maso T
,
Socher E ,
Versees W ,
Moeller A ,
Zunke F ,
Arnold P
Cryo-TEM structure of beta-glucocerebrosidase in complex with its transporter LIMP-2.
Dobert JP,
Schafer JH ,
Dal Maso T ,
Ravindran P ,
Huard DJE,
Socher E ,
Schildmeyer LA,
Lieberman RL ,
Versees W ,
Moeller A ,
Zunke F ,
Arnold P
(2025) Nat Commun , 16 , 3074 - 3074
,
Dal Maso T ,
Ravindran P ,
Huard DJE,
Socher E ,
Schildmeyer LA,
Lieberman RL ,
Versees W ,
Moeller A ,
Zunke F ,
Arnold P
(2025) Nat Commun , 16 , 3074 - 3074
Grant Support:
- Michael J. Fox Foundation: MJFF-17240; MJFF-020706; MJFF-022745 (United States)
- Other government: Interdisciplinary Center for Clinical Research (IZKF); Jochen-Kalden funding programme N8
- Other government: Fonds voor Wetenschappelijk Onderzoek; G031324N
- Other government: VUB Strategic Research Program Financing; SRP95
- Other private: Friedrich-Ebert Foundation; no grant number