EMD-50336
Cryo-EM structure of the ternary DARPin NY_1/HLA-A0201/NY-ESO1 complex.
EMD-50336
Single-particle3.1 Å
Deposition: 17/05/2024Map released: 28/05/2025
Last modified: 10/12/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Ternary complex formed between the DARPin NY_1 and HLA-A0201/hb2m/NY-ESO1_157-165(9V)
Fitted models: 9fe1
Deposition Authors: Schulte T, Wallden K, Carroni M, Sandalova T, Walser M, Mueller S, Venetz N, Achour A
Sample: Ternary complex formed between the DARPin NY_1 and HLA-A0201/hb2m/NY-ESO1_157-165(9V)
Fitted models: 9fe1
Deposition Authors: Schulte T, Wallden K, Carroni M, Sandalova T, Walser M, Mueller S, Venetz N, Achour A
Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes.
Venetz-Arenas N,
Schulte T,
Muller S,
Wallden K,
Fischer S,
Resink T 
,
Kadri N,
Paladino M,
Pina N,
Radom F,
Villemagne D ,
Bruckmaier S,
Cornelius A,
Hospodarsch T,
Alici E,
Ljunggren HG,
Chambers BJ,
Han X,
Sun R,
Carroni M,
Levitsky V,
Sandalova T,
Walser M,
Achour A
(2025) iScience , 28 , 113926 - 113926
,
Kadri N,
Paladino M,
Pina N,
Radom F,
Villemagne D ,
Bruckmaier S,
Cornelius A,
Hospodarsch T,
Alici E,
Ljunggren HG,
Chambers BJ,
Han X,
Sun R,
Carroni M,
Levitsky V,
Sandalova T,
Walser M,
Achour A
(2025) iScience , 28 , 113926 - 113926
Grant Support:
- Knut and Alice Wallenberg Foundation: (Sweden)
- Cancerfonden: (Sweden)
- Swedish Research Council: (Sweden)